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In the brain, a consecutive imbalance toward the pro-oxidant side impairs cellular functions, leading to neurodegeneration

Oxidative stress occurs when the organism is subjected to a variety of internal and external environmental stimuli and there is an imbalance between oxidative and antioxidant processes

doi: 10.1038/s41467-018-04524-x 54 Van PulKMVuylstekeRJCLMVan De VenRTe VeldeEARutgersEJTVan Den TolPMet al

found that GSTM2 expression was much higher in ovarian teratoma mesenchymal stem cell-like cells than in normal cells and that p38 was highly inhibited in the teratomas 43

examined the activities of antioxidant enzymes in hemolysed erythrocytes

PST (Phenol Sulphur Transferase) deficiency This enzyme helps detoxify chemicals and certain neurotransmitters