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A high percentage of cells in S-phase is associated with a better clinical response to MTX (11) and is accompanied by increased expression of genes involved in nucleotide biosynthesis, such as TYMS , CPTS , and an MTX target enzyme, DHFR ( 11)

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The suppression of BPC 157-induced VEGFR2, Akt, and eNOS activation and tube formation by dynasore, an inhibitor of endocytosis, further supported the importance of VEGFR2 internalization underlying the mechanism of BPC 157 effect [122]

Acknowledgement The patient in this manuscript has given written informed consent to the publication of his case details and photographs

Public written comments can be submitted to docket FDA-2025-N-6895 through July 22, 2026

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