ROS are present in cells and tissues at low but measurable concentration which is determined by the balance between the rate of production versus the clearance by different antioxidant enzymes (SOD, glutathione peroxidase and catalase) and compounds (glutathione, ascorbate, -tocopherol, -carotene).12 A complex functional modulation of several proteins occurs upon cellular oxidative stress.13-15 In particular, this is accomplished through modification of proteins since several aminoacids, such as Tryptophan, Tyrosine, Histidine and particularly Cysteine, are direct targets of ROS.16 ROS-mediated protein modification can affect both protein structure and function and protein stability
Azarova I, Klyosova E, Polonikov A
Biomacromolecules 19 , 40844097 (2018)
Probing the Influence of Citrate-Capped Gold Nanoparticles on an Amyloidogenic Protein
Personalized Protocols: We often combine Glutathione with Vitamin C to enhance the brightening and anti-aging effects
however, combining these peptides may exhibit far more important features