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10.1038/s41598-017-15054-9 108

Int J Biol Sci (2018) 15:13847

Heidari, N., Sajedi, F., Mohammadi, Y., Mirjalili, M., & Mehrpooya, M

doi: 10.1016/j.ijantimicag.2009.10.009 179 KimGK

Blocks NNMT in fat cells In 3T3-L1 mouse fat cells, 30 M of 5-Amino-1MQ for 24 hours strongly lowered 1-MNA levels direct proof of NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)

However, further efforts are needed to standardize in vitro protocols for evaluating Epitalons biological activity and to clarify its precise molecular mechanisms, which remain only partially understood