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Intracellular ferrous iron (Fe 2+ ) levels are tightly regulated through multiple mechanisms including import via transferrin receptor 1 and CD44, export via SLC40A1, storage via ferritin, lysosomal ferritinophagy mediated by NCOA4, and relocalization of iron to the cytosol [5]

The net effect: adipocytes become metabolically sluggish, oxidizing less fat, storing more energy, and resisting signals that would normally promote energy expenditure

If you know your levels are low, B12 supplements are a great start, but you're going to be playing catch-up, so dont expect things to be back to normal immediately

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Otherwise, you're gambling," he said.