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Calreticulin (CRT) has been shown to be related to the pathogenesis of RA

Chowdari Gurram P, Satarker S, Nampoothiri M (2024) Recent advances in the molecular signaling pathways of substance P in Alzheimers disease: link to neuroinflammation associated with toll-like receptors

But, they be very unlikely to even touch on the issues of building the evidence around them, just as they haven't for dietary supplements in disease states

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When this occurs, additional free radicals are produced which, in turn, can result in more extensive damage to cells and tissues