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Fondaparinux (antithrombin activator) and the direct thrombin inhibitor drugs including hirudin and bivalirudin significantly inhibited procoagulant activity of hepatocytes in vitro (Stephenne et al., 2012)

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Another essential component concerns pharmacokinetics (PK) and pharmacodynamics (PD)

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The lipid modification at the Cagri N-terminus is poorly resolved in the cryo-EM maps for AMYR complexes, but some limited density was visible for the Glu linker and a very short segment of the acyl chain in the AMY 1 R complex (Fig

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