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B cell-specific demethylation: a novel role for the intronic kappa chain enhancer sequence
The Phase I trial of the novel HDAC inhibitor Bisthianostat (BIS, oral tablets, starting dose of 100 mg, escalated to 200/400 mg, administered twice weekly) demonstrated good safety as a monotherapy, with no Grade 3/4 non-hematologic toxicities
Keep the solution at room temperature (typically below 25 C or 30 C), unless otherwise instructed by the pharmacist
The naturally occurring parent molecule (thymosin beta-4) is present in virtually every cell in the body, which provides a theoretical basis for its favorable safety profile the body already produces and processes this molecule as part of normal physiology
& Moazed, D
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