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4.4 Apoptosis Apoptosis plays an essential role in the pathophysiology of TBI, and inhibiting it may offer potential benefits in overcoming the adverse effects of TBI and facilitating functional recovery (Unnisa et al., 2023)

The concept of audiometric zero was established in large-scale measurements at the 1939 Worlds Fair in New York and San Francisco, defining the mean hearing threshold of 19-year-olds at 1 kHz as the 0 dB hearing level (HL)

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This is due to saturation of the IGF-1R receptors, resulting in the remaining IGF-1 circulating in the blood attaching to bone and gastrointestinal tissue [1, 16]