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Curcumin and its reduced metabolites undergo conversion to glutaric acid and sulfate in both in vitro and in vivo conditions

Although synergistically inducing ICD is beneficial for anti-tumor immunity, it may affect protective mechanisms in normal tissues that share common signaling, such as the ER stress/ROS axis

Also, it offers short processing times and low operating temperatures (Paka et al

There can be comorbidities for patients suffering from diabetes, Cushing disease or most important of all HIV positive patients

McCubrey JA, Lahair MM, Franklin RA: Reactive oxygen species-induced activation of the MAP kinase signaling pathways