Many of the studies reviewed did not involve the isolation, structural elucidation, or characterization of bioactive compounds
Dopaminergic SN cells are usually pigmented with black neuromelanin, produced from of the autoxidation [57] or enzyme-mediated oxidation [58] of the cytoplasmic dopamine (DA) to DA-o-quinone, which then Polymerizes
Replacing the acetyl group with the propionyl or isobutyryl group on nitrogen gave 3f and 3g in 80 and 61% yield, respectively
Four proline residues (positions 3, 4, 5, and 8) introduce conformational rigidity that may hinder protease recognition sites
ischemic injury occurs to organs (see section on ischemia)
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