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Tregs also highly express immune checkpoint molecules (e.g., CTLA-4, PD-1, GITR), which bind receptors on immune cells to inhibit effector activity [36]

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The study concluded that the appropriate needle depth was DSFP thickness + 7 mm, but which has the problem of being difficult to apply in a real-time vaccination setting

Dose: 2 mg (2000 mcg) daily after Week 1 titration