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The extracted details, such as authors, study population, study design, definition of smoking status, median follow-up time and outcomes, were systematically documented and organised in a table

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These findings support the concept that glucagon receptor activation may be therapeutically useful when balanced by GLP-1 receptor signaling, although retatrutide currently provides the most prominent evidence for triple receptor agonism

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the GLP-1 side is covered in how semaglutide stimulates GLP-1 receptor activity