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While cholinesterase inhibitors have shown positive effects on cognitive functions and measures of clinical global state (82), a systematic review of randomized controlled trials did not find lecithin to be more beneficial than placebo in the treatment of patients with cognitive impairment, vascular dementia, AD, or mixed dementia (83)

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If peptide-based approaches can provide meaningful benefit at lower cost and with fewer side effects, that combination would make them attractive as either standalone or adjunctive therapy

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