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Keeping the amount of GNPTAB cDNA constant (400 ng), while increasing the amount of LYSET cDNA, resulted in rising levels of PTase activity in a dose-dependent manner

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These effects are likely partly due to local increases in extracellular glutamate causing excitotoxicity, and reduced trophic support [e.g., platelet-derived growth factor (PDGF)] from astrocytes (Tognatta et al., 2020)

a Proteomics Approach