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The driver may be mast-cell-mediated or systemic rather than NF-B-local, so dose escalation will not reach it see the mast-cell note under Phenotype Considerations

Vitamin B12 plays a role in breaking down fats, proteins, and carbohydrates, ensuring that the body efficiently uses the food it consumes for energy

Preclinical studies in animal models have yielded several noteworthy findings

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Do acid-lowering agents affect vitamin B12 status in older adults