In BRAF V600E-mutant CRC, tumor cells often exhibit an initial response to BRAF inhibitors, but frequently develop resistance through reactivation of the MAPK pathway, commonly via KRAS amplification or MEK mutations [76]
The resulting accumulation of squalene within the fungal cell increases membrane permeability and distorted intracellular organization [168]
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however, it was unclear whether the increase was on the kinetic or the transcriptional level or even whether GSSG reduction was increased
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