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Regulatory T Cells (Tregs): GPX4-maintained redox balance is essential for regulatory T cell (Treg) function, as its deficiency disrupts immune homeostasis through lipid peroxidation-mediated impairment, potentially driving pathogenesis in autoimmune diseases like SLE and RA (73)

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Moreover, rats treated with 1% neohesperidin dihydrochalcone for 1 month showed reduced amygdala neuroinflammation via suppression of cAMP/PKA pathway activity, restoration of cortical 5-HT, DA, and NE levels, and reversal of anxiety- and depression-like behaviors (Jiang et al., 2023)

Effects on renal cortical and liver mitochondria swelling