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FOXO4-DRI Preclinical Evidence and Translational Challenges: From Mouse Models to Clinical Reality FOXO4-DRI demonstrated selective senolytic activity in the landmark Baar et al

The review covered multiple studies demonstrating that activation of the angiotensin IV receptor (AT4/HGF/c-Met) system improves cognitive performance in animal models

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Preclinical studies have explored downstream effects on antioxidant signalling, extracellular matrix remodelling, and gene-expression responses in cultured cells