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Limb, trunk and some head muscles arise from cells of somitic origin, whereas the remainder of the head muscles derive from cells of the paraxial head mesoderm and the prechordal mesoderm [1, 1115]

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Therapies such as ambroxol, a small molecule with lysosomal-enhancing properties, and buntanetap tartrate, a compound that can reduce neurotoxic protein levels, are some of the novel therapies currently under investigation for their potential to restore cellular balance and slow the progression of PD