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The results of experimental studies indicate that low IGF-1 concentrations could play a role in the course of ALS disease by accelerating neurodegenerative changes and worsening clinical symptoms 9

The exception is other copper-containing peptides, where cumulative copper exposure becomes a consideration

Aging Disease 6:1

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These cells can be reprogrammed metabolically using FAO inhibitors (etomoxir), glutathione-depleting drugs (buthionine sulfoximine), or ferroportin blockers to decrease iron efflux

Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation