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Monzani D, Casolari L, Guidetti G, Rigatelli M

Mechanistically, ZFP36L1 deficiency stabilized TNFa and Jag1 mRNA, activating JAG1-NOTCH signaling (which reprograms hepatocyte into bipotent progenitors) and p21 (which prevents progenitor proliferation and promotes hepatocyte senescence)

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The higher prevalence of anhedonic symptoms observed in our study further supports the notion that nicotine may be used to manage emotional discomfort, reinforcing the need for integrated approaches that address both nicotine dependence and mental health challenges