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Strong dual inducers (rifampin, carbamazepine, phenytoin) decrease apixaban exposure by approximately 54% and should be avoided [1]

Mild cutaneous reactions will self-resolve

396,397 According to a meta-analysis of 408 papers involving stress protocols, the most commonly used stressors for CUMS models are food and water deprivation, light cycle modification, wet bedding, cage tilting, social stress, and forced swimming

Two weeks of mild headaches is normal