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Liver Dysfunction and Damage The livers role in processing fats, proteins, and balancing energy is disrupted by high Hcy, leading to fat buildup and inflammation

Xiang, T

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Belaidi, P

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We have chosen prpTDP-43 A315T mice for our analyses, because this mouse model of TDP-43 pathology was generated based on the A315T mutation detected in the TARDP gene of ALS patients, who had TDP-43 pathology in their cortex 19 , and because the mouse model strictly recapitulated many aspects of the disease, including progressive CSMN degeneration 16