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Gln depletion therapy can inhibit Gln metabolism in tumor cells, but in colon cancer, it has been observed that Gln depletion promotes the expression of the aspartate/glutamate transporter SLC1A3 in tumor cells, increasing the intracellular glutamate concentration and promotes Gln synthesis

Chemosphere 288 , 132631 (2022)

Llabani E, Hicklin RW, Lee HY, Motika SE, Crawford LA, Weerapana E, et al