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inhibition of VMAT2 reduces available dopamine that can be released into the synaptic cleft, which can reduce the symptoms associated with dopamine hypersensitivity

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This paper highlights the importance of geneenvironment interactions in the multistep process required for ALS to manifest clinically

Design of mouse experiments For the calculation of the estimated sample size a power analysis was performed according to the formula: n= 2(Z /2 +Z ) 2 * 2 / 2 , with a power (1-) of 80% and a significance () of 0.05