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Systemic administration (injectable or oral), which is less common than topical use and not part of approved or standard applications, would theoretically carry different safety considerations requiring appropriate clinical evaluation, though limited research on parenteral administration in animals has suggested acceptable safety profiles at moderate doses

Fiber supplements should be introduced gradually and taken with sufficient water to avoid worsening gastrointestinal discomfort

5) Case examples Dermatology: Customized topical creams (multi-agent formulations not commercially available)

Obes Surg (2017) 27:82636

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Challenges in treating patients with major depressive disorder: the impact of biological and social factors