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Theoretical Risks and Safety Nuance Preclinical Safety Observations While no major adverse events are reported in the limited human data, researchers note theoretical concerns based on animal models

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This stability is considered a direct consequence of its gastric origin: a peptide evolved to remain functional in the highly acidic, protease-rich environment of the stomach

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[7] High-dose methionine may antagonize the therapeutic effect of L-dopa-carbidopa regimens by increasing peripheral methylation of the drug complex, potentially reducing central bioavailability