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In contrast, hepatocyte activities of LD are much lower (relative to plasma) than those of the other two enzymes, and plasma activities of LD are several times higher than those of AST and ALT

Patients with active, moderate-to-severe GO, are generally treated with high doses intravenous glucocorticoids (ivGCs) and/or orbital radiotherapy

However, the stratum corneum acts as a formidable barrier to drug permeation

Increased Risk of Cardiovascular Disease: Some studies suggest that vitamin B12 deficiency may be associated with an increased risk of cardiovascular disease due to its role in regulating homocysteine levels

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Inactivation of regulatory-associated protein of mTOR (Raptor)/mammalian target of rapamycin complex 1 (mTORC1) signaling in osteoclasts increases bone mass by inhibiting osteoclast differentiation in mice