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Finally, the results of one randomized controlled trial in 601 patients with common forms of retinitis pigmentosa indicated that supplementation with 400 IU/day of synthetic vitamin E (equivalent to 180 mg/day of RRR --tocopherol) modestly but significantly accelerated the loss of retinal function compared to placebo (123)

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All-cause mortality and cardiovascular outcomes with sodium-glucose Co-transporter 2 inhibitors, glucagon-like peptide-1 receptor agonists and with combination therapy in people with type 2 diabetes

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AD-specific lactylation dysregulation centers on the glycolysis-H4K12la-PKM2 positive feedback loop in hippocampal microglia and tau lactylation in vulnerable neuronsthis dual-cell lactylation network directly promotes A phagocytosis impairment and tau pathological aggregation (Zhao and Xu, 2022), a mechanism not observed in ischemia-induced acute injury or PDs dopaminergic neuron-specific degeneration

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