NO-releasing agents, such as JS-K ( O 2 -(2,4-dinitrophenyl)-1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate) 123 and PABA/NO ( O 2 -[2,4-dinitro-5-( N -methyl- N -4 carboxyphenylamino)phenyl] 1- N , N -dimethylamino)diazen-1-ium-1,2-diolate) 124 , are able to induce differentiation and cell death in a variety of cancer cells through GSH consumption, DNA synthesis inhibition and inhibition of enzymes involved in the defense against cell damage
Sitohang is with the Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr
Introduction Approximately 700,000 US military personnel were deployed for the Gulf War (GW) ( The neurological category for both sets of criteria includes psychiatric symptoms such as anxiety, post-traumatic stress disorder (PTSD), and depression, which are shown at increased rates among GW veterans since the war ended ( Gulf War Illness is hypothesized to be related to neurotoxic exposures during the GW, which may have caused central nervous system (CNS) dysregulation ( Research has demonstrated that each component of the neurotoxic triad, including glutamate excitotoxicity, oxidative stress, and neuroinflammation, have been implicated individually in the underlying pathophysiology of anxiety, PTSD, and depression ( Glutamate is also involved in psychiatric disorders because it is involved in the release of other neurotransmitters, including monoaminergic (e.g., serotonin and dopamine) and GABAergic transmission, which are often targets of psychiatric medications ( Preclinical and clinical pharmacology studies have also implicated the glutamatergic system in these disorders through known and suspected drug mechanisms ( One potential adjunct treatment for these psychiatric conditions is the low glutamate diet
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Other polyphenol compounds including apigenin, baicalin, and quercetin, were documented to activate the Nrf2 pathway [106,107,108,109,110]
High-throughput total cupric ion reducing antioxidant capacity of biological samples determined using flow injection analysis and microplate-based methods
