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Early hydration improvements may appear within 1 to 2 weeks

Evidence of urate-induced long-term functional alterations also points to immune cell dysregulation, but further studies are needed to determine the metabolic adaptations of innate immune cells to urate as well as more in-depth studies to discuss the mechanisms by which UA regulates innate immunity

UGT, uridine-5-diphospho-glucuronosyltransferase

Sirisha et al

I am not convinced the data is fully there yet." Tatem said he expects the hearings to be a "hard-fought battle," but hopes committee members will consider what he described as real-world data from tens of millions of doses administered between 2014 and 2023

Luo et al., 2023)