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Supplementary Materials The following supporting information can be downloaded at: Table S1: displaying the five approved anti-TNF- inhibitors in chronological order of first approval by Food and Drug Administration (FDA)

Both have distinct yet complementary mechanisms that, when combined, may offer synergistic benefits

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Human medical use remains uncertain because BPC-157 lacks FDA approval, standardized dosing, and strong controlled clinical evidence

Because of the nonspecific activation of lytic peptide, they discovered that, when the peptide enters the cell line, it specifically cleaves secreted metalloproteinases, breaking the peptide bond [48]

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