The significant cell damage and loss result in decreased dopamine concentration within the striatum and the dysfunction of the nigrostriatal pathway
10.1016/j.diabres.2005.10.007 19
Additionally, diminished CD47 expression has been reported in RBCs from individuals with chronic CKD ( 3.3 Inflammation In CKD patients, the accumulation of uremic toxins and chronic immune activation drive the overproduction of pro-inflammatory cytokines, including C-reactive protein (CRP), interleukin-6 (IL-6), and interleukin-1 (IL-1) (Ogawa et al., 2018)
Supporting this, another study using a D-galactose-induced aging model in rats demonstrated that regular swimming exercise led to significant neuroprotective effects
Since Dihexa is a relatively new compound, there is limited data on its long-term effects
10.1002/jimd.12009 38 GarakaniA.JaffeR