The synthetic alternatives have the sequence of amino acids reversed and the alpha chirality changed[2]
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[2] For this reason, elevated serum homocysteine over 15 micromol/L and methylmalonic acid (MMA) over 0.271 micromol/L are considered better indicators of B 12 deficiency, rather than relying only on the concentration of B 12 in blood
Its mainly used to correct or prevent a B12 shortfall, and to support general energy and wellbeing where a shortfall is the likely cause
If thats a concern for you, see Transitioning Off BPC-157 TB-500: Avoiding Rebound Inflammation
[DOI] [PMC free article] [PubMed] [Google Scholar] 231.Brohan J., Goudra B.G