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Similarly, NAD + levels appear reduced in preclinical models of age-associated diseases, including ataxia-telangiectasia (A-T), mitochondrial myopathies, and Alzheimers disease (AD), and disease-matched clinical samples 114,242,243,244,245,246

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For example, the chemotherapeutic agent doxorubicin generates ROS as part of its mechanism of action, contributing to its cytotoxic effects

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Fischer W, et al

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This may be particularly relevant for individuals with nutrient deficiencies or impaired nutrient absorption

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