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Phase 2 trials reported greater weight loss than either monotherapy

Monroy-Ruiz J, Sevilla M, Carrn R, Montero MJ (2011) Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats

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Do not start at the 500 mg three-times-daily dose used in most metabolic RCTs until four weeks of combined use have confirmed glucose stability