Heterogeneity and publication bias Heterogeneity of included studies was evaluated using Cochrane's Q test and I-square test
As with all health supplements sold in Singapore, manufacturers are required to comply with HSA's Health Products (Health Supplements) Regulations, which include GMP manufacturing standards and label claim accuracy requirements
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The test should be interpreted with a qualified healthcare provider alongside clinical thyroid markers, antibody levels, and inflammatory profiles
After a brief vortexing and sonication, the samples underwent centrifugation, and the supernatant, rich in metabolites, was carefully transferred to ice and dried using a nitrogen desiccator