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However, the results of these authors are inconsistent with those of Whitcomb et al

Side effects and safety concerns The combination amplifies risks significantly

Glossary AMPK-AMP activated protein kinase AKT protein kinase B ACOX1 peroxisomal acyl-CoA oxidase 1 BCL-2 B-cell lymphoma 2 CAT catalase C/EBP enhancer-binding protein COX-2 cyclooxygenase-2 GPx glutathione reductase GST glutathione-S-transferase GLUT4 glucose transporter 4 GSH glutathione HbA1C glycated hemoglobin HDL high density lipoprotein HO-1 heme oygenase-1 LDL low density lipoprotein NJK-c-Jun N terminal kinases MDA malonaldehyde iNOS inducible nitric oxide synthase INF- interferon gamma IL interleukin MAPK mitogen-activated protein kinase MCP-1 monocyte chemoattractant protein-1 NF- nuclear factor kappa T1D/T1D type 1/2 diabetes mellitus TNF- tumor necrosis factor alpha TBARS thiobarbituric acid reactive species PDE-5 phosphodiesterase type 5 PKC protein kinase C PPAR peroxisome proliferator-activated receptor gamma SIRT1 NAD-dependent deacetylase SOD superoxide dismutase SREBP1c sterol regulatory element-binding protein 1c WHO World Health Organization VEGF vascular endothelial growth factor References 1 Abd EldaimM

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PMID: 38517048 J Cosmet Dermatol2024 Feb;23(2):639-647

2016;29:240 NIH Public Access