Based on this ability, CPPs effectively deliver various therapeutic agents, including peptide drugs, small-molecule drugs, and nucleic acids, into cells 57
Rawlings TM, Tryfonos M, Makwana K, Taylor DM, Brosens JJ, Lucas ES (2024) Endometrial assembloids to model human embryo implantation in vitro
385,387 PF1801 displays its anti-inflammatory effects by lowering levels of inflammatory mediators such as TNF, IL-6, and HMGB1, and enhances the cells antioxidant capability by upregulating molecules like Nfe2l2, Hmox1, Gclm, and Nqo1, which further improves cellular defense against oxidative stress and protects them from further damage
This engineering approach demonstrates how protein-protein interactions can be selectively disrupted using stabilized peptide research tools, an approach that has informed peptide engineering more broadly
If they don't test absorption, they don't care whether it works
New England Journal of Medicine (2025) The REDEFINE 2 Phase 3 trial evaluated CagriSema in 1,206 adults with overweight or obesity and type 2 diabetes in a 68-week, double-blind, placebo-controlled design
