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In preclinical models this dual mechanism produced greater weight loss than a maximal semaglutide dose, and in a Phase 2 diabetes trial higher survodutide doses reduced weight more than semaglutide though human superiority has not been formally established in head-to-head registration trials

Cagrilintide is used to study biological mechanisms in controlled research environments

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Regulatory factors and signaling networks The Nrf2-ARE axis is a key signaling pathway regulating GSH synthesis and metabolism

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Galluzzi L, Kepp O, Trojel-Hansen C, Kroemer G