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Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, HIV infection, AIDS, certain endocrine disorders, iron deficiency, and subtotal gastrectomy)

However, these patients had multiple risk factors for b12 deficiency beyond semaglutide use, including previous gastric surgery that permanently alters stomach anatomy and reduces intrinsic factor production

The research team reported that administration of melanotan II led to induced transient anorexia for approximately 5 days

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