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In addition, GSH has been shown to regulate nitric oxide homeostasis (Hogg, 2002), modulate the activity of proteins by post-translational modification (protein S-glutathionylation) (Pompella et al., 2003), and modulate the activity of neurotransmitter receptors (Oja et al., 2000)

These are precautionary considerations extrapolated from class data

Safety and Tolerability Preclinical studies suggest that 5-Amino-1MQ is well-tolerated with a favorable safety profile

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The D-Nle-Trp-Ile-NH(CH 2 ) 5 CONH 2 analog had intermediate inhibitory activity, and the D-Nle-Met-Ile-NH(CH 2 ) 5 CONH 2 analog showed no ability to effect on Met activation

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