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The authors declare that they have no conflicts and were not involved in the journal's review or decision regarding this manuscript
Side Effects and Safety Profile Like other incretin-based therapies, the most commonly reported side effects are gastrointestinal, including: Nausea Vomiting Diarrhea Reduced appetite Full safety data is still being evaluated in ongoing Phase 3 clinical trials
[101] demonstrated that the insulin/mTOR/STAT3 pathway acted through the transcription of the Ikaros gene to induce the commitment of hemotopoietic progenitors to the lymphoid lineage
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An attempt to identify Nrf2 target genes in cancer cells revealed that Nrf2 directly activates the genes whose products are involved in the pentose phosphate pathway and nicotinamide adenine dinucleotide phosphate (NADPH) production, such as glucose-6-phosphate dehydrogenase (G6PD), phosphogluconate dehydrogenase (PGD), transketolase (TKT) and transaldolase 1 (TALDO1), and malic enzyme 1 (ME1
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