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In the United States, according to the National Youth Tobacco Survey (NYTS), in 2020, current e-cigarette use among high school students was highest in the Midwest region (27.1%) and lowest in the Northeast region (18.5%)

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To guarantee the energy production of hepatocytes from OXPHOS, p53 exerts its pleiotropic role in limiting glycolysis and diverting pyruvate toward the tricarboxylic acid cycle (TCA) 30

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