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3 Ferroptosis in RCC 3.1 Ferroptosis signaling pathway and RCC 3.1.1 HIF-iron metabolism pathway involved in ferroptosis and RCC ccRCC is associated closely with mutations in the VHL gene that lead to the activation of HIF-1 and HIF-2 via a pseudohypoxia mechanism, resulting in the transcription of genes involved in tumor progression (76)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 215.Wang J, Hu Y, Liu P, Xu X

Linus Pauling Institute Oregon State University Updated in March 2003 by: Jane Higdon, Ph.D

The table below outlines three hypothetical approaches

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