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Certain metallic cations, such as copper (Cu) and iron (Fe 2+/3+ ) may contribute significantly to the generation of ROS

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Non-native disulfides are resolved by reduced PDIs, which are regenerated by GSH, leading to the formation of GSSG

In particular, oral dysbiosis and proton pump inhibitor usage facilitate the translocation of otherwise oral-indigenous bacteria to the intestine ( Porphyromonas gingivalis , a periodontopathic bacterium, may predispose hosts to systemic inflammation and autoimmunity by inducing LGS

Glutathione inhalation treatments in cystic fibrosis: the interference of airway -glutamyltransferase

Abbott RD, Sadowski A, Alt AG (2019) Efficacy of the Autoimmune Protocol Diet as Part of a Multi-disciplinary, Supported Lifestyle Intervention for Hashimotos Thyroiditis