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However, ICP27 inhibits mRNA 3 processing of all PASs that we tested, including viral PASs (Fig

developed a probe utilizing redox-active Fe (II) as a chemical target to visualize ferroptosis processes

Beyond the observed increase in female lifespan, we show that pharmacologic blockade of IGF-1R signaling preserves, to various degrees, many aspects of healthspan, including neuromuscular function and endurance, and attenuates the age-related increase in diastolic dysfunction, systemic inflammation, and neoplasias in females