doi: 10.4049/jimmunol.2200452 [DOI] [PMC free article] [PubMed] [Google Scholar] 283.Sollberger G, Choidas A, Burn GL, et al
3 Interactions of autophagy with the cGAS-STING pathway 3.1 cGAS The interplay between autophagy and cGAS occurs through (i) cGAS-Beclin-1 interaction that promotes autophagic degradation of cytosolic dsDNA, (ii) cGAS-LC3 interaction that promotes micronucleophagy, and (iii) degradation of cGAS through p62-mediated selective autophagy ( Figure 3 )
placebo-controlled study confirmed these effects in real-world use
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Intriguingly, a recent study showed that exposure to sublethal hydrogen peroxide led to a long-term genome-wide decrease in DNA methylation