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Higher doses (12.515 mg/week) may be used in subsequent phases if tolerated and clinically indicated

Drge, 2002a,b

Epigenetic changes enable cells to rapidly respond to environmental variations

There are many factors to consider

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When adverse effects occurred, they were typically mild and transient, with the most common being mild to moderate headaches (similar frequency to placebo groups), minor injection site reactions (redness, slight swelling), and gastrointestinal effects at higher oral doses (nausea, diarrhea)